@nieagatka ty masz racje z tym dual-trigger to (ovitrell) hcg plus gonapeptyl. To w takim razie jak nazywa się ten mój zastrzyk :-) nie istotne.
@jasani szukałam i znalazłam.
Gonadotropin-releasing hormone (GnRH) agonists were first suggested for final oocyte maturation by Gonen et al. in 1990, as it is able to trigger endogenous release of both FSH and LH [
4]. With a shorter mean duration of LH surge of about 34 hours, it is similar to the natural cycle duration of 48 hours [
5], effectively reducing the incidence of OHSS in high responders [
6,
7]. However, some problems surfaced with the substitution of GnRH-agonists as trigger. Kummer et al. discovered that the risk of empty follicle syndrome was increased following isolated GnRH-agonist trigger due to a suboptimal LH surge [
8]. Additionally, increased early pregnancy loss and decreased rates of ongoing pregnancy were noted by multiple studies [
9,
10]. As such, the idea of a dual trigger was developed [
11]. Indeed, the hCG component of dual trigger could serve as a rescue trigger in case of poor response to GnRH-agonist, which occurs in about 2.71% of a study population [
12].
To gonapeptyl jest na dojrzewanie komórki a ovitrell ma ratować jeżeli coś pójdzie nie tak. Bo zdarzały się puste pecherzyki przy samym gonapeptylu. Ma być owulacja i to jak najlepsza i tyle:-)
Since its development, multiple investigations have shown the benefits of using a dual trigger for final oocyte maturation in normal responders [
11,
13], including an improvement in total number of retrieved oocytes, MII oocytes, rates of embryo implantation, clinical pregnancy, and live birth rates [
14].